Clinical Trials - Cancer

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Contact Us

For more information about cancer-related clinical trials, contact:

Nannette Faile
NJFaile@lexhealth.org

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Clinical Trials

Locally available Clinical Trials

General

SUP 01

A Phase 3, Multicenter, Randomized, Double-Blind, Active-Controlled Study of the Safety and Efficacy of Rolapitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting (CINV) in Subjects Receiving Moderately Emetogenic Chemotherapy (MEC).

Breast

BRE 156

A Phase II Study of NK012 in Locally Advanced Non-Resectable Metastatic Breast Cancer Patients with Triple Negative Phenotype.

BRE 197

A Randomized Phase II Study of Eribulin/Cyclophosphamide or Docetaxel/Cyclophosphamide as Neoadjuvant Therapy in Locally Advanced HER2-Negative Breast Cancer

BRE 186

Phase 2 Trial of Eribulin in Patients Who Do Not Achieve Pathologic Complete Response (pCR) Following Neoadjuvant Chemotherapy

BRE 193

A randomized multicenter, double-blind, placebo-controlled comparison of chemotherapy plus trastuzumab plus placebo versus chemotherapy plus trastuzumab plus pertuzumab as adjuvant therapy in patients with operable HER2-positive primary breast cancer

RTOG 1005

A Phase III Trial of Accelerated Whole Breast Irradiation with Hypofractionation Plus Concurrent Boost Versus Standard Whole Breast Irradiation Plus Sequential Boost for Early-Stage Breast Cancer

S1007

A Phase III, Randomized Clinical Trial of Standard Adjuvant Endocrine Therapy +/- Chemotherapy in Patients with 1-3 Positive Nodes, Hormone Receptor-Positive and HER2-Negative Breast Cancer with Recurrence Score (RS) of 25 or Less.

Colorectal

GI 162

A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of GS-6624. Combined with FOLFIRI as Second Line Treatment for Metastatic KRAS or BRAF Mutant Colorectal Adenocarcinoma that Has Progressed Following a First Line Oxaliplatin- andFluoropyrimidine-Containing Regimen.

GI 155

Randomized Double-Blind, Placebo Controlled, Phase II Study of FOLFOX/ Bevacizumab with or without Met MAb as First-Line Treatment for Patients with Metastatic Colorectal Cancer

OUTCOMES 04

A retrospective cohort study of infusion reactions due to Vectibix (Panitumumab)

GI 141

A randomized Phase 2 study evaluating the safety and efficiency of various drugs in Metastatic and Relapsed/Refractory colorectal cancer.

Kidney

GU 75

Randomized, Multicenter, Open-label, Active-Controlled, Phase 2 Study of LY2510924 and Sunitinib versus Sunitinib in Patients with Metastatic Renal Cell Carcinoma

Lung - Non-Small Cell

Iressa Clinical Access Program

An Open Label, Multi-Center IRESSA, Clinical Access Program of Gefitinib 250 mg (Iressa) for the continued treatment of patients in the United States who are currently benefiting or have benefited from Gefitinib treatment

S0819

A Randomized, Phase III Study Comparing Carboplatin/Paclitaxel or Carboplatin/Paclitaxel/Bevacizumab with or without Concurrent Cetuximab in Patients with Advanced Non-Small Cell Lung Cancer

LUN 222

A Randomized, Phase III, Multicenter, Double-Blind, Placebo-Controlled Study Evaluating The Efficacy And Safety Of Metmab In Combination With Tarceva (Erlotinib), In Patients With Met Diagnostic-Positive Non-Small Cell Lung Cancer (NSCLC), Who Have Received Standard Chemotherapy For Advanced Or Metastatic Disease.

LUN 219

A Randomized, Open-label, Multicenter, Phase 3 Study to Compare the Efficacy and Safety of Eribulin with Treatment of Physician’s Choice in Subjects with Advanced Non-Small Cell Lung Cancer

LUN 196

TOPPS Phase II trial for patients with stage III/IV Non-Small Cell Lung Cancer.

LUN 186

Phase II study for patients with Stage IB, II and III Non-Small-Cell lung cancer.

Lung - Small Cell

LUN 225

A Phase 1/2 Study to Assess the Safety and Efficacy of Lorvotuzumab Mertansine (IMGN901) in Combination with Carboplatin/Etoposide in Patients with Advanced Solid Tumors including Extensive Stage Small Cell Lung Cancer.

Melanoma

MEL 28

A Phase III, Randomized, Double-Blinded Study Comparing the combination of the BRAF Inhibitor, GSK2118436 and the MEK Inhibitor, GSK1120212 to Each Single Agent Combined with Placebo in Subjects with Advanced (Stage IIIc) or Metastatic (Stage IV) BRAF V600E/K Mutation-Positive Melanoma

Ovary

GYN 26

Phase I/II study for patients with Sates III/IV or Relapse/Refractory ovarian cancer.

Pancreas

GI 164

A Phase 2 Randomized, Double-Blinded, Placebo-Controlled Study to Evaluate the Efficacy and Safety of GS-6624 Combined with Gemcitabine as First Line Treatment for Metastatic Pancreatic Adenocarcinoma.

Prostate

P10-3

A Registry of Sipuleucel-T Therapy in Men with Advanced Prostate Cancer.

Tissue Banking

Southeast Biorepository System Protocol (Two Studies)

Lexington Medical Center has launched 3 cancer-related studies based on our tissue banking program

Chronic Lymphocytic Leukemia (CLL)

OBS 03

Connect CLL Registry Protocol

CLL 02

A Phase I/II Study of Fludarabine, Rituximab, and Lenalidomide in Minimally Treated and Untreated Patients with Chronic Lymphocytic Leukemia

Non-Hodgkin's Lymphoma (NHL) - Diffuse Large Cell

LYM 67

An Open-Label, Randomized, Phase 2 Study to Assess the Effectiveness of RCHOP With or Without VELCADE in Previously Untreated Patients with Non- Germinal Center B-Cell like Diffuse Large B-Cell Lymphoma

LYM 74

A Phase III, Multicenter, Randomized Trial Comparing the Efficacy of GA101 in Combination with CHOP (G-CHOP) Versus Rituximab and CHOP (R-CHOP) in Previously Untreated Patients with CD20-Positive Diffuse Large B-Cell Lymphoma (DLBCL)

Multiple Myeloma

MM 23

Phase II Study for the Evaluation of Bendamustine, Bortezomib and Dexamethasone (BBD) in the First-Line Treatment of patients with Multiple Myeloma Who are not Candidates for High Dose Chemotherapy.


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